منابع مشابه
The mitotic exit network
What is it? The mitotic exit network – commonly known by the acronym MEN — is a signal transduction cascade which triggers the exit of mitosis. The MEN has been characterized in the budding yeast Saccharomyces cerevisiae, and the protein names below refer to components from this species, though many are conserved in vertebrates. The main switch of this cascade is the small G protein Tem1 and it...
متن کاملMitotic exit in mammalian cells
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متن کاملProtein Phosphatases Drive Mitotic Exit
Mitosis is the final stage of the cell cycle that results in the formation of two independent daughter cells with an equal and identical complement of chromosomes (Figure 1). This requires a complex series of events such as nuclear envelope breakdown, spindle formation, equal chromosome segregation, packaging of chromosomes into daughter nuclei and constriction of the plasma membrane at the cel...
متن کاملMitotic exit in two dimensions.
Metaphase of mitosis is brought about in all eukaryotes by activation of cylin-dependent kinase (Cdk1), whereas exit from mitosis requires down-regulation of Cdk1 activity and dephosphorylation of its target proteins. In budding yeast, the completion of mitotic exit requires the release and activation of the Cdc14 protein-phosphatase, which is kept inactive in the nucleolus during most of the c...
متن کاملMitotic Exit: Delaying the End without FEAR
Activation of Cdc14 phosphatase, controlled by a signalling cascade known as the mitotic exit network, is the final switch that drives cells from mitosis into the next cell cycle. The recent discovery of a novel network that regulates early Cdc14 activation has revealed the unexpected existence of a two-step control of mitotic exit.
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2001
ISSN: 1097-2765
DOI: 10.1016/s1097-2765(01)00422-1